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Blocking expression of inhibitory receptor NKG2A overcomes tumor resistance to NK cells

12 Mar 2019

Abstract excerpt

A key mechanism of tumor resistance to immune cells is mediated by expression of peptide-loaded HLA-E in tumor cells, which suppresses natural killer (NK) cell activity via ligation of the NK inhibitory receptor CD94/NKG2A. Gene expression data from approximately 10,000 tumor samples showed widespread HLAE expression, with levels correlating with those of KLRC1 (NKG2A) and KLRD1 (CD94). To bypass HLA-E...

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PMID: 30860984
DOI: 10.1172/jci123955

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