NKG2A expression identifies a subset of human Vδ2 T cells exerting the highest antitumor effector functions.

doi:10.1016/j.celrep.2021.109871

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Article

NKG2A expression identifies a subset of human Vδ2 T cells exerting the highest antitumor effector functions.

Cell reports - 19 Oct 2021

Cazzetta Valentina, Bruni Elena, Terzoli Sara, Carenza Claudia, Franzese Sara, Piazza Rocco, Marzano Paolo, Donadon Matteo, Torzilli Guido, Cimino Matteo, Simonelli Matteo, Bello Lorenzo, Villa Anna, Tan Likai, Ravens Sarina, Prinz Immo, Supino Domenico, Colombo Federico S, Lugli Enrico, Marcenaro Emanuela, Vivier Eric, Della Bella Silvia, Mikulak Joanna, Mavilio Domenico

Abstract excerpt

Human Vδ2 cells are innate-like γδ T effectors performing potent immune surveillance against tumors. The constitutive expression of NKG2A identifies a subset of Vδ2 T cells licensed with an intrinsic hyper-responsiveness against cancer. Indeed, the transcriptomic profiles of NKG2A+ and NKG2A- cells characterize two distinct "intralineages" of Vδ2 T lymphocytes that appear early during development, keep their...

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PMID: 34686325
DOI: 10.1016/j.celrep.2021.109871

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