Article

HERV-derived epitopes represent new targets for T-cell based immunotherapies in ovarian cancer

2024-07-17

Abstract excerpt

<h4>Background</h4> Ovarian cancer represents the most lethal gynecological cancer with poor results of checkpoint inhibitors. Human endogenous retroviruses (HERVs) are aberrantly expressed by tumor cells and may represent a source of shared T cell epitopes for cancer immunotherapy regardless of the tumor mutational burden. <h4>Methods</h4> A transcriptomic analysis based on RNA-sequencing (RNA-seq) was develope...

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Literature Corpus work: 19f0f547-8a60-5d90-92c5-0fc57c6b099a
DOI: 10.1101/2024.07.13.603392

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