Article

Hantaan virus-derived peptides that stabilize HLA-E could abrogate inhibition of CD56 <sup>dim</sup> NKG2A <sup>+</sup> NK cells

2024-11-07

Abstract excerpt

NK cells could participate in the pathogenesis process of virus infectious diseases through the inhibitory receptor CD94/NKG2A interacting with HLA-E/virus-derived peptide complex. However, the effects and mechanisms of NKG2A-HLA-E axis-mediated NK cell responses in hemorrhagic fever with renal syndrome (HFRS) caused by Hantaan virus (HTNV) infection remain unclear. Single-cell RNA sequencing and flow cytometry we...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e71239d3-99d5-5d7a-92aa-caa76ca06850
DOI: 10.1101/2024.11.05.622026

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Hantaan virus-derived peptides that stabilize HLA-E could abrogate inhibition of CD56 <sup>dim</sup> NKG2A <sup>+</sup> NK cellsDOI 10.1101/2024.11.05.622026Read

Interaction of a dengue virus NS1-derived peptide with the inhibitory receptor KIR3DL1 on natural killer cellsSemantic proximity Read

Hantaan Virus Infection Induces Both Th1 and ThGranzyme B+ Cell Immune Responses That Associated with Viral Control and Clinical Outcome in HumansSemantic proximity Read

Human antigen-specific memory natural killer cell responses develop against HIV-1 and influenza virus and are dependent on MHC-E restrictionSemantic proximity Read

Structural insights into activation of antiviral <scp>NK</scp> cell responsesSemantic proximity Read

HLA-E*01:01 + HLA-E*01:01 genotype confers less susceptibility to COVID-19, while HLA-E*01:03 + HLA-E*01:03 genotype is associated with more severe disease.Semantic proximity Read

HIV-1 Control by NK Cells via Reduced Interaction between KIR2DL2 and HLA-C∗12:02/C∗14:03.Semantic proximity Read

Human NK Cells and Herpesviruses: Mechanisms of Recognition, Response and AdaptationSemantic proximity Read

Innate receptors with high specificity for HLA class I–peptide complexesSemantic proximity Read

NKG2A expression identifies a subset of human Vδ2 T cells exerting the highest antitumor effector functions.Semantic proximity Read

Control of Human Viral Infections by Natural Killer CellsSemantic proximity Read

HLA-F expression on CD4 T cells in HIV-1 is linked to the presence of viremia and modulated by KIR3DS1Semantic proximity Read

HLA-E Peptide Repertoire and Dimorphism—Centerpieces in the Adaptive NK Cell Puzzle?Semantic proximity Read