Article

Functional Impact of Glycosylation and Splicing Variants of LRIG1 on EGFR Proteostasis in Cancer

2025-02-06

Abstract excerpt

LRIG1, a membrane glycoprotein, has emerged as a significant stem cell marker and negative regulator of receptor tyrosine kinases (RTKs), including EGFR. Glycosylation is a major post-translational modification, which plays a crucial role in protein function and stability. In cancer biology, abnormal glycosylation can serve as a biomarker and contribute to pathogenesis. We aimed to investigate the effects of glyco...

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Literature Corpus work: a929ec94-cb83-5b1b-9a68-1263419c81b3
DOI: 10.1101/2025.02.05.636756

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