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Article

Functional impact of glycosylation of LRIG1 on EGFR proteostasis in cancer.

Journal of biochemistry - 11 Mar 2026

Kondo Jumpei, Nagao Himari, Oyama Koki, Minamiura Akari, Aoki Shuto, Sakon Daisuke, Nakayama Honoka, Takamatsu Shinji, Miyoshi Eiji

Abstract excerpt

LRIG1, a membrane glycoprotein, has emerged as a significant stem cell marker and negative regulator of receptor tyrosine kinases (RTKs), including epidermal growth factor receptor (EGFR). Glycosylation is a major post-translational modification, which plays a crucial role in protein function and stability. In cancer biology, abnormal glycosylation can contribute to pathogenesis, which can also serve as a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 41498460
DOI: 10.1093/jb/mvag001

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EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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