Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of Activating Mutations in the Transmembrane and Extracellular Domains of EGFR.

Biochemistry - 4 Oct 2022

Wagner Anja, Galicia-Andrés Edgar, Teufl Magdalena, Gold Lukas, Obinger Christian, Sykacek Peter, Oostenbrink Chris, Traxlmayr Michael W

Abstract excerpt

The epidermal growth factor receptor (EGFR) is frequently mutated in human cancer, most notably non-small-cell lung cancer and glioblastoma. While many frequently occurring EGFR mutations are known to confer constitutive EGFR activation, the situation is less clear for rarely detected variants. In fact, more than 1000 distinct EGFR mutations are listed in the Catalogue of Somatic Mutations in Cancer (COSMIC), but...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to Carcinoma, Non-Small-Cell Lung

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ErbB Receptors

Share to Lung Cancer Treatments and Mutations

Share to Lung Neoplasms

Share to Mutation

Share to Protein Kinase Inhibitors

Share to RNA modifications and cancer

Source

Open in PubMed Open full text

Identifiers

PMID: 36148499
DOI: 10.1021/acs.biochem.2c00384
PMCID: PMC9535940

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of Activating Mutations in the Transmembrane and Extracellular Domains of EGFR.PMID 36148499Read ↗

<i>In Vitro</i> Validation of Computationally Predicted Oncogenic Driver Mutations in EGFR Tyrosine Kinase DomainSemantic proximity Read ↗

Comprehensive mutational scanning of EGFR reveals TKI sensitivities of extracellular domain mutants.Semantic proximity Read ↗

A Molecular Dynamics Protocol for Rapid Prediction of EGFR Overactivation and Its Application to the Rare Mutations S768I, S768N, D761NSemantic proximity Read ↗

Computational and Experimental Characterization of Patient Derived Mutations Reveal an Unusual Mode of Regulatory Spine Assembly and Drug Sensitivity in EGFR Kinase.Semantic proximity Read ↗

PhosphoFlowSeq - A High-throughput Kinase Activity Assay for Screening Drug Resistance Mutations in EGFR.Semantic proximity Read ↗

An unbiased in vitro screen for activating epidermal growth factor receptor mutationsSemantic proximity Read ↗

Computational algorithms for in silico profiling of activating mutations in cancer.Semantic proximity Read ↗

Discrimination of driver and passenger mutations in epidermal growth factor receptor in cancer.Semantic proximity Read ↗

Landscape of activating cancer mutations in FGFR kinases and their differential responses to inhibitors in clinical use.Semantic proximity Read ↗

Prediction and prioritization of rare oncogenic mutations in the cancer Kinome using novel features and multiple classifiers.Semantic proximity Read ↗

Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation.Semantic proximity Read ↗

Effects of N361 Glycosylation on Epidermal Growth Factor Receptor Biological FunctionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.