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Article

Role of N-glycosylation in EGFR ectodomain ligand binding.

Proteins - 1 Aug 2017

Azimzadeh Irani Maryam, Kannan Srinivasaraghavan, Verma Chandra

Abstract excerpt

The epidermal growth factor receptor (EGFR) is a tyrosine kinase protein, overexpressed in several cancers. The extracellular domain of EGFR is known to be heavily glycosylated. Growth factor (mostly epidermal growth factor or EGF) binding activates EGFR. This occurs by inducing the transition from the autoinhibited tethered conformation to an extended conformation of the monomeric form of EGFR and by stabilizing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28486782
DOI: 10.1002/prot.25314

Genes

EGFR
EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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