Article

CAR Macrophages for SARS-CoV-2 Immunotherapy

2020-07-27

Abstract excerpt

Targeted therapeutics for the treatment of coronavirus disease 2019 (COVID-19), especially severe cases, are currently lacking. As macrophages have unique effector functions as a first-line defense against invading pathogens, we genetically armed human macrophages with chimeric antigen receptors (CARs) to reprogram their phagocytic activity against SARS-CoV-2. After investigation of CAR constructs with different i...

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Literature Corpus work: 801e9d43-b538-5dc0-9180-d547c30c1106
DOI: 10.1101/2020.07.26.222208

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