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TAM receptors in phagocytosis: Beyond the mere internalization of particles

19 Aug 2023

Abstract excerpt

TYRO3, AXL, and MERTK constitute the TAM family of receptor tyrosine kinases, activated by their ligands GAS6 and PROS1. TAMs are necessary for adult homeostasis in the immune, nervous, reproductive, skeletal, and vascular systems. Among additional cellular functions employed by TAMs, phagocytosis is central for tissue health. TAM receptors are dominant in providing phagocytes with the molecular machinery...

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PMID: 37596991
DOI: 10.1111/imr.13267

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