Article

Translation regulation of ATF4 by the termination complex Hbs1-Pelo is required for visual system development and function

2025-10-10

Abstract excerpt

Inherited retinal diseases are a class of genetically heterogenous disorders characterized by mutations in genes required for retinal function, resulting in progressive loss of vision in human patients. One such deletion mutation in the translation termination factor, HBS1L, results in a suite of developmental anomalies in human patients, including progressive vision loss defects. HBS1L, and its interaction partne...

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Literature Corpus work: 801e165a-9c46-5d18-ad2c-e681dbbe6848
DOI: 10.1101/2025.10.08.681214

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