Article
A protein-trap allele reveals roles for Drosophila ATF4 in photoreceptor degeneration, oogenesis and wing development.
Disease models & mechanisms - 1 Mar 2022
Vasudevan Deepika, Katow Hidetaka, Huang Huai-Wei, Tang Grace, Ryoo Hyung Don
Abstract excerpt
Metazoans have evolved various quality control mechanisms to cope with cellular stress inflicted by external and physiological conditions. ATF4 is a major effector of the integrated stress response, an evolutionarily conserved pathway that mediates adaptation to various cellular stressors. Loss of function of Drosophila ATF4, encoded by the gene cryptocephal (crc), results in lethality during pupal development....
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