Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Epithelial Endoplasmic Reticulum Stress Enhances the Risk of Muc5b-Associated Lung Fibrosis

15 Sept 2022

Abstract excerpt

Abstract The gain-of-function minor allele of the MUC5B (mucin 5B, oligomeric mucus/gel-forming) promoter (rs35705950) is the strongest risk factor for idiopathic pulmonary fibrosis (IPF), a devastating fibrotic lung disease that leads to progressive respiratory failure in adults. We have previously demonstrated that Muc5b overexpression in mice worsens lung fibrosis after bleomycin exposure and have hypothesized...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cystic Fibrosis Research Advances
Share to Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Medical Imaging and Pathology Studies

Source

Identifiers

PMID: 36108173
DOI: 10.1165/rcmb.2022-0252oc

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Epithelial Endoplasmic Reticulum Stress Enhances the Risk of Muc5b-Associated Lung FibrosisPMID 36108173Read ↗

XBP1S Regulates MUC5B in a Promoter Variant–Dependent Pathway in Idiopathic Pulmonary Fibrosis Airway EpitheliaSemantic proximity Read ↗

IRE1α drives lung epithelial progenitor dysfunction to establish a niche for pulmonary fibrosisSemantic proximity Read ↗

Idiopathic Pulmonary Fibrosis: A Genetic Disease That Involves Mucociliary Dysfunction of the Peripheral Airways.Semantic proximity Read ↗

Regulation of MUC5B Expression in Idiopathic Pulmonary Fibrosis.Semantic proximity Read ↗

Identification of Impacted Pathways and Transcriptomic Markers as Potential Mediators of Pulmonary Fibrosis in Transgenic Mice Expressing Human IGFBP5Semantic proximity Read ↗

Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals.Semantic proximity Read ↗

Cell-type-specific ATF6α programs regulate epithelial mitochondrial homeostasis and pericyte remodeling during physiological and exposure-accelerated lung agingSemantic proximity Read ↗

A MUC5B polymorphism associated with Idiopathic Pulmonary Fibrosis mediates overexpression through decreased CpG methylation and C/EBPβ transcriptional activationSemantic proximity Read ↗

The Role of FABP5 in Radiation-Induced Human Skin FibrosisSemantic proximity Read ↗

Genes, other than Muc5b, are associated with bleomycin-induced lung injury.Semantic proximity Read ↗

Sensitization of the UPR by loss of PPP1R15A promotes fibrosis and senescence in IPF.Semantic proximity Read ↗

The MUC5B-associated variant rs35705950 resides within an enhancer subject to lineage- and disease-dependent epigenetic remodeling.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.