Article

<i>Atf6</i> <sup>-/-</sup> mouse photoreceptors exhibit novel ciliary rootlet defect

2026-02-19

Abstract excerpt

ATF6 is a regulator of the Unfolded Protein Response that maintains cellular homeostasis during ER stress. In patients, ATF6 mutations cause photoreceptor dystrophy and sensorineural hearing loss. Atf6 -/- mice develop progressive hearing loss with stereocilia disorganization and mild retinal dysfunction, suggesting that ATF6 loss may impair the structural integrity of sensory cells. To test this possibility, we...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 59b9eadc-ecc8-58a6-8488-ffb4ab5870f4
DOI: 10.64898/2026.02.18.701862

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>Atf6</i> <sup>-/-</sup> mouse photoreceptors exhibit novel ciliary rootlet defectDOI 10.64898/2026.02.18.701862Read

Mutations in unfolded protein response regulator ATF6 cause hearing and vision loss syndrome.Semantic proximity Read

The Endoplasmic Reticulum Proteostasis Regulator ATF6 is Essential for Human Cone Photoreceptor DevelopmentSemantic proximity Read

Pathomechanisms of ATF6-Associated Cone Photoreceptor Diseases.Semantic proximity Read

Achromatopsia mutations target sequential steps of ATF6 activation.Semantic proximity Read

Endoplasmic reticulum stress in human photoreceptor diseases.Semantic proximity Read

ATF6 Is Mutated in Early Onset Photoreceptor Degeneration With Macular Involvement.Semantic proximity Read

Multi-omic analysis of photoreceptor alterations during early-onset retinal degeneration in <i> Mfrp <sup>-/-</sup> </i> miceSemantic proximity Read

ATF6alpha optimizes long-term endoplasmic reticulum function to protect cells from chronic stress.Semantic proximity Read

A protein-trap allele reveals roles for <i>Drosophila</i> ATF4 in photoreceptor degeneration, oocyte maturation and wing developmentSemantic proximity Read

RNA Sequence Reveals Mouse Retinal Transcriptome Changes Early after Axonal InjurySemantic proximity Read

Neurodegeneration: Keeping ATF4 on a Tight LeashSemantic proximity Read

TAZ ( <i>Wwtr1</i> ) deficiency leads to ER stress and mitochondrial dysfunction in a mouse model of Fuchs’ endothelial corneal dystrophySemantic proximity Read