Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pathomechanisms of ATF6-Associated Cone Photoreceptor Diseases.

Advances in experimental medicine and biology - 1 Jan 2019

Chiang Wei-Chieh Jerry, Kroeger Heike, Chea Lulu, Lin Jonathan H

Abstract excerpt

Activating transcription factor 6 (ATF6) is a key regulator of the unfolded protein response (UPR). In response to endoplasmic reticulum (ER) stress, ATF6 is transported from the ER to the Golgi apparatus where it is cleaved by intramembrane proteolysis, releasing its cytosolic fragment. The cleaved ATF6 fragment, which is a basic leucine zipper (bZip) transcription factor, translocates to the nucleus and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Activating Transcription Factor 6
Share to Endoplasmic Reticulum Stress

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Golgi Apparatus

Share to Mutation

Share to Protein Folding

Share to Retinal Cone Photoreceptor Cells

Share to Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 31884629
DOI: 10.1007/978-3-030-27378-1_50
PMCID: PMC7643264

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pathomechanisms of ATF6-Associated Cone Photoreceptor Diseases.PMID 31884629Read ↗

Achromatopsia mutations target sequential steps of ATF6 activation.Semantic proximity Read ↗

The Endoplasmic Reticulum Proteostasis Regulator ATF6 is Essential for Human Cone Photoreceptor DevelopmentSemantic proximity Read ↗

ATF6 Is Mutated in Early Onset Photoreceptor Degeneration With Macular Involvement.Semantic proximity Read ↗

Mutations in unfolded protein response regulator ATF6 cause hearing and vision loss syndrome.Semantic proximity Read ↗

<i>Atf6</i> <sup>-/-</sup> mouse photoreceptors exhibit novel ciliary rootlet defectSemantic proximity Read ↗

Multiexon deletion alleles of ATF6 linked to achromatopsia.Semantic proximity Read ↗

Molecular mechanism of ATF6 in unfolded protein response and its role in diseaseSemantic proximity Read ↗

Macular maldevelopment in ATF6-mediated retinal dysfunction.Semantic proximity Read ↗

Neurodegeneration: Keeping ATF4 on a Tight LeashSemantic proximity Read ↗

Endoplasmic reticulum stress in human photoreceptor diseases.Semantic proximity Read ↗

Mutation of ATF6 causes autosomal recessive achromatopsia.Semantic proximity Read ↗

ATF6 Is a Transcription Factor Specializing in the Regulation of Quality Control Proteins in the Endoplasmic ReticulumSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.