Article

Genome-scale detection of positive selection in 9 primates predicts human-virus evolutionary conflicts

2017-04-27

Abstract excerpt

Hotspots of rapid genome evolution hold clues about human adaptation. Here, we present a comparative analysis of nine whole-genome sequenced primates to identify high-confidence targets of positive selection. We find strong statistical evidence for positive selection acting on 331 protein-coding genes (3%), pinpointing 934 adaptively evolving codons (0.014%). Our stringent procedure and quality control of alignmen...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7fffe375-afb7-532d-b523-e11750ef505b
DOI: 10.1101/131680

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genome-scale detection of positive selection in 9 primates predicts human-virus evolutionary conflictsDOI 10.1101/131680Read

Genome-scale detection of positive selection in nine primates predicts human-virus evolutionary conflicts.Semantic proximity Read

Systematic detection of positive selection in the human-pathogen interactome and lasting effects on infectious disease susceptibility.Semantic proximity Read

Rapid detection of positive selection in genes and genomes through variation clusters.Semantic proximity Read

An ancient viral epidemic involving host coronavirus interacting genes more than 20,000 years ago in East AsiaSemantic proximity Read

Host-Virus Arms Races Drive Elevated Adaptive Evolution in Viral Receptors.Semantic proximity Read

Viruses rule over adaptation in conserved human proteinsSemantic proximity Read

Immune genes are hotspots of shared positive selection across birds and mammalsSemantic proximity Read

Immune-driven positive and balancing selection in human populationsSemantic proximity Read

Pervasive Positive Selection on Virus Receptors Driven by Host-Virus Conflicts in Mammals.Semantic proximity Read

Ancient adaptive evolution of the primate antiviral DNA-editing enzyme APOBEC3G.Semantic proximity Read

Positive natural selection in the human lineage.Semantic proximity Read

Human genome variability, natural selection and infectious diseases.Semantic proximity Read