Article
Rapid detection of positive selection in genes and genomes through variation clusters.
Genetics - 1 Aug 2007
Wagner Andreas
Abstract excerpt
Positive selection in genes and genomes can point to the evolutionary basis for differences among species and among races within a species. The detection of positive selection can also help identify functionally important protein regions and thus guide protein engineering. Many existing tests for positive selection are excessively conservative, vulnerable to artifacts caused by demographic population history, or...
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