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Article

Pervasive Positive Selection on Virus Receptors Driven by Host-Virus Conflicts in Mammals.

Journal of virology - 27 Sept 2021

Wang Wenqiang, Han Guan-Zhu

Abstract excerpt

Viruses hijack cellular proteins, known as viral receptors, to initiate their infections. Viral receptors are subject to two conflicting directional forces, namely, negative selection to maintain their cellular function and positive selection resulted from the ever-changing host-virus arms race. Much remains unclear about how viral receptors evolved in mammals and whether viral receptors from different mammal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34319153
DOI: 10.1128/JVI.01029-21
PMCID: PMC8482839

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