Understanding fibroblast activation protein (FAP): Substrates, activities, expression and targeting for cancer therapy

Abstract excerpt

Fibroblast activation protein (FAP) is best known for its heightened expression in tumour stroma. This atypical serine protease has both dipeptidyl peptidase and endopeptidase activities, cleaving substrates at a post-proline bond. FAP expression is difficult to detect in non-diseased adult organs, but is greatly upregulated in sites of tissue remodelling, which include liver fibrosis, lung fibrosis,...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cardiac Structural Anomalies and Repair
• Share to Peptidase Inhibition and Analysis
• Share to Protease and Inhibitor Mechanisms