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GBA mutation exacerbates α-synuclein pathology with involvement of ROS and p38 MAPK signaling in Parkinson's disease.

International immunopharmacology - 1 Oct 2026

Xu Hong, Tang Yu-Ting, Dong Wei-Ling, Liu Man-Hua, Wang Fen, Liu Chun-Feng, Chen Ju-Ping

Abstract excerpt

The glucocerebrosidase (GBA) gene is the second most significant genetic risk factor for Parkinson's disease (PD) pathogenesis. Notably, GBA mutations not only enhance PD susceptibility in the general population but also accelerate disease progression. Nevertheless, the precise molecular mechanisms underlying GBA-associated PD pathogenesis remain elusive. In this study, we demonstrated that the L444P mutation in...

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PMID: 42378827
DOI: 10.1016/j.intimp.2026.117089

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