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The lysosomal β-glucocerebrosidase strikes mitochondria: implications for Parkinson's therapeutics.

Brain : a journal of neurology - 1 Aug 2024

Rubilar Juan Carlos, Outeiro Tiago Fleming, Klein Andrés D

Abstract excerpt

Parkinson's disease is a neurodegenerative disorder primarily known for typical motor features that arise due to the loss of dopaminergic neurons in the substantia nigra. However, the precise molecular aetiology of the disease is still unclear. Several cellular pathways have been linked to Parkinson's disease, including the autophagy-lysosome pathway, α-synuclein aggregation and mitochondrial function....

Topics

Humans
Glucosylceramidase
Lysosomes
Mitochondria
Parkinson Disease
Animals
alpha-Synuclein
Autophagy
Mutation

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 38437875
DOI: 10.1093/brain/awae070

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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