Lineage Memory and Convergent Adaptation Dictate the Single-Cell and Spatial Architecture of Brain Malignancies

Abstract excerpt

How diverse cancer lineages navigate the draconian central nervous system environment—whether constrained by ancestral ontogeny or driven by convergent adaptation—remains a fundamental biological paradox. To decode this, we integrated extensive in-house and public resources to construct the largest single-cell atlas of primary and secondary brain malignancies (>550,000 cells). We demonstrate that malignant cells b...

Topics

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• Immune Evasion
• Lymphocyte Activation
• Lymphocytes, Tumor-Infiltrating
• Mice, Nude
• Myeloid Cells
• Principal Component Analysis
• RNA-Seq
• Single-Cell Analysis

Identifiers and source

Literature Corpus work

7fc0b26b-8574-5857-84ce-fc457f5ae246

DOI

10.64898/2026.06.15.732237