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Transcriptomic Hallmarks of Tumor Plasticity and Stromal Interactions in Brain Metastasis

1 Apr 2019

Abstract excerpt

The brain is a major site of relapse for several cancers, yet deciphering the mechanisms of brain metastasis remains a challenge because of the complexity of the brain tumor microenvironment (TME). To define the molecular landscape of brain metastasis from intact tissue in vivo, we employ an RNA-sequencing-based approach, which leverages the transcriptome of xenografts and distinguishes tumor cell and stromal...

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PMID: 31018140
DOI: 10.1016/j.celrep.2019.03.085

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