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Article

Cellular architecture of human brain metastases.

Cell - 17 Feb 2022

Gonzalez Hugo, Mei Wenbin, Robles Isabella, Hagerling Catharina, Allen Breanna M, Hauge Okholm Trine Line, Nanjaraj Ankitha, Verbeek Tamara, Kalavacherla Sandhya, van Gogh Merel, Georgiou Stephen, Daras Mariza, Phillips Joanna J, Spitzer Matthew H, Roose Jeroen P, Werb Zena

Abstract excerpt

Brain metastasis (BrM) is the most common form of brain cancer, characterized by neurologic disability and an abysmal prognosis. Unfortunately, our understanding of the biology underlying human BrMs remains rudimentary. Here, we present an integrative analysis of >100,000 malignant and non-malignant cells from 15 human parenchymal BrMs, generated by single-cell transcriptomics, mass cytometry, and complemented...

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Identifiers

PMID: 35063085
DOI: 10.1016/j.cell.2021.12.043
PMCID: PMC8857062

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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