Article

Transmembrane protein CD69 acts as an S1PR1 agonist

2023-02-15

Abstract excerpt

The activation of Sphingosine-1-phosphate receptor 1 (S1PR1) by S1P promotes lymphocyte egress from lymphoid organs, a process critical for immune surveillance and T cell effector activity 1-4 . Multiple drugs that inhibit S1PR1 function are in use clinically for the treatment of autoimmune diseases. Cluster of Differentiation 69 (CD69) is an endogenous negative regulator of lymphocyte egress that interacts with...

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Literature Corpus work: 7fa2dad6-ad40-5810-913f-71a46f6612b5
DOI: 10.1101/2023.02.13.528406

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