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Article

Rapid induction of medullary thymocyte phenotypic maturation and egress inhibition by nanomolar sphingosine 1-phosphate receptor agonist.

Proceedings of the National Academy of Sciences of the United States of America - 16 Sept 2003

Rosen Hugh, Alfonso Christopher, Surh Charles D, McHeyzer-Williams Michael G

Abstract excerpt

Only a small number of T cells generated in the thymus each day are selected to replenish the peripheral T cell pool. Much is known about thymic selection; however, little is known of the mechanisms regulating medullary maturation and the release of mature T cells into the blood. Here we demonstrate a rapid acceleration of medullary thymocyte phenotypic maturation through loss of CD69 induced by sphingosine...

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Identifiers

PMID: 12954982
DOI: 10.1073/pnas.1832725100
PMCID: PMC196901

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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