Article
Molecular characterization of binding of calcium and carbohydrates by an early activation antigen of lymphocytes CD69.
Biochemistry - 12 Aug 2003
Pavlícek Jirí, Sopko Bruno, Ettrich Rüdiger, Kopecký Vladimír, Baumruk Vladimír, Man Petr, Havlícek Vladimír, Vrbacký Marek, Martínková Ludmila, Kren Vladimír, Pospísil Miloslav, Bezouska Karel
Abstract excerpt
CD69 is the earliest leukocyte activation antigen playing a pivotal role in cellular signaling. Here, we show that a globular C-terminal domain of CD69 belonging to C-type lectins binds calcium through Asp 171, Glu 185, and Glu 187 with K(d) approximately 54 microM. Closure of the calcium-binding site results in a conformational shift of Thr 107 and Lys 172. Interestingly, structural changes in all of these amino...
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