Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Landscape of Non-canonical Cysteines in Human VH Repertoire Revealed by Immunogenetic Analysis

1 Jun 2020

Abstract excerpt

Human antibody repertoire data captured through next-generation sequencing (NGS) has enabled deeper insights into B cell immunogenetics and paratope diversity. By analyzing large public NGS datasets, we map the landscape of non-canonical cysteines in human variable heavy-chain domains (V H s) at the repertoire level. We identify remarkable usage of non-canonical cysteines within the heavy-chain...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Glycosylation and Glycoproteins Research
Share to Monoclonal and Polyclonal Antibodies Research
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32610132
DOI: 10.1016/j.celrep.2020.107831

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Landscape of Non-canonical Cysteines in Human VH Repertoire Revealed by Immunogenetic AnalysisPMID 32610132Read ↗

A Broad Role for Cysteines in Bovine Antibody DiversitySemantic proximity Read ↗

On the humanization of VHHs: Prospective case studies, experimental and computational characterization of structural determinants for functionalitySemantic proximity Read ↗

Landscape of variable domain of heavy‐chain‐only antibody repertoire from alpacaSemantic proximity Read ↗

Functional Divergence in the Affinity and Stability of Non-Canonical Cysteines and Non-Canonical Disulfide Bonds: Insights from a VHH and VNAR Study.Semantic proximity Read ↗

Distinct types of VHHs in AlpacaSemantic proximity Read ↗

Structural diversity of B-cell receptor repertoires along the B-cell differentiation axis in humans and miceSemantic proximity Read ↗

High-Resolution Description of Antibody Heavy-Chain Repertoires in HumansSemantic proximity Read ↗

Unveiling inverted D genes and D-D fusions in human antibody repertoires unlocks novel antibody diversitySemantic proximity Read ↗

Structural Diversity of B-Cell Receptor Repertoires along the B-cell Differentiation Axis in Humans and MiceSemantic proximity Read ↗

Reshaping antibody diversity.Semantic proximity Read ↗

Diversity in the Cow Ultralong CDR H3 Antibody Repertoire.Semantic proximity Read ↗

Characterization of a high‐affinity human antibody with a disulfide bridge in the third complementarity‐determining region of the heavy chainSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.