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Large-scale sequence and structural comparisons of human naive and antigen-experienced antibody repertoires

25 Apr 2016

Abstract excerpt

Elucidating how antigen exposure and selection shape the human antibody repertoire is fundamental to our understanding of B-cell immunity. We sequenced the paired heavy- and light-chain variable regions (VH and VL, respectively) from large populations of single B cells combined with computational modeling of antibody structures to evaluate sequence and structural features of human antibody repertoires at...

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PMID: 27114511
DOI: 10.1073/pnas.1525510113

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