Towards development of Nav1.7 channel modulators for pain treatment: A comparison of mexiletine effect in two cell models by automated patch clamp

Abstract excerpt

The Nav1.7 voltage-gated sodium channel recently emerged as a candidate target for developing analgesic drugs due to its contribution to nociception and association with different pain disorders. Despite extensive research, no selective modulator of Nav1.7 has been put into clinic yet. Meanwhile, some non-selective sodium channel blockers, such as lidocaine and mexiletine (Mex), have been used for treating...