Article
Effects of ranolazine on wild-type and mutant hNav1.7 channels and on DRG neuron excitability.
Molecular pain - 8 Jun 2010
Estacion Mark, Waxman Stephen G, Dib-Hajj Sulayman D
Abstract excerpt
BACKGROUND: A direct role of sodium channels in pain has recently been confirmed by establishing a monogenic link between SCN9A, the gene which encodes sodium channel Nav1.7, and pain disorders in humans, with gain-of-function mutations causing severe pain syndromes, and loss-of-function mutations causing congenital indifference to pain. Expression of sodium channel Nav1.8 in DRG neurons has also been shown to be...
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