Effects of ranolazine on wild-type and mutant hNav1.7 channels and on DRG neuron excitability.

doi:10.1186/1744-8069-6-35

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Article

Effects of ranolazine on wild-type and mutant hNav1.7 channels and on DRG neuron excitability.

Molecular pain - 8 Jun 2010

Estacion Mark, Waxman Stephen G, Dib-Hajj Sulayman D

Abstract excerpt

BACKGROUND: A direct role of sodium channels in pain has recently been confirmed by establishing a monogenic link between SCN9A, the gene which encodes sodium channel Nav1.7, and pain disorders in humans, with gain-of-function mutations causing severe pain syndromes, and loss-of-function mutation...

Topics

Acetanilides
Angina Pectoris
Cell Line
Ganglia, Spinal
Humans
Mutation
NAV1.7 Voltage-Gated Sodium Channel
Piperazines
Ranolazine
Sodium Channel Blockers
Sodium Channels

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