[Neuropathic pain associated with Nav1.7 mutations: clinical picture and treatment].

doi:10.1007/s00115-012-3621-7

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Article

[Neuropathic pain associated with Nav1.7 mutations: clinical picture and treatment].

Der Nervenarzt - 1 Dec 2013

Doppler K, Sommer C

Abstract excerpt

Voltage-gated sodium channels are essential for electrogenesis in excitable cells. The isoform Nav1.7 is primarily expressed in nociceptors. Mutations of the SCN9A gene, which codes for the α-subunit of Nav1.7, are the cause of primary erythromelalgia and paroxysmal extreme pain disorder, two rar...

Topics

DNA Mutational Analysis
Erythromelalgia
Humans
NAV1.7 Voltage-Gated Sodium Channel
Neuralgia
Pain
Pain Threshold
Polymorphism, Single Nucleotide
Rectum

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