Article

Na <sub>V</sub> 1.7 mRNA and protein expression in putative projection neurons of the human spinal dorsal horn

2023-02-05

Abstract excerpt

Na V 1.7, a membrane-bound voltage-gated sodium channel, is preferentially expressed along primary sensory neurons, including their peripheral & central nerve endings, axons, and soma within the dorsal root ganglia and plays an integral role in amplifying membrane depolarization and pain neurotransmission. Loss- and gain-of-function mutations in the gene encoding Na V 1.7, SCN9A , are associated with a complete...

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Literature Corpus work: 3b703009-3d15-5beb-8fba-2c13314dc986
DOI: 10.1101/2023.02.04.527110

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