Article

Loss of ninein interferes with osteoclast formation and causes premature ossification

2023-11-06

Abstract excerpt

Ninein is a centrosome protein that has been implicated in microtubule anchorage and centrosome cohesion. Mutations in the human ninein gene have been linked to Seckel syndrome and to a rare form of skeletal dysplasia. However, the role of ninein in skeletal development remains unknown. Here, we describe a ninein knockout mouse with advanced endochondral ossification during embryonic development. Although the lon...

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Literature Corpus work: 7f90b118-e767-51ca-af85-df6368c476a0
DOI: 10.1101/2023.11.03.565572

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