Article
Mouse fibroblast growth factor 9 N143T mutation leads to wide chondrogenic condensation of long bones.
Histochemistry and cell biology - 1 Apr 2020
Harada Masayo, Akita Keiichi
Abstract excerpt
Long bones of the appendicular skeleton are formed through endochondral ossification. Endochondral bone formation initiates with mesenchymal condensation, followed by the formation of a cartilage template which is replaced by bone. Fibroblast growth factor 9 (FGF9) regulates bone development. Fgf9-/- mice exhibit disproportionate shortening of proximal skeletal elements. Fgf9 missense mutations in mice and humans...
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