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Article

Microtubule assembly affects bone mass by regulating both osteoblast and osteoclast functions: stathmin deficiency produces an osteopenic phenotype in mice.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Sept 2011

Liu Hongbin, Zhang Rongrong, Ko Seon-Yle, Oyajobi Babatunde O, Papasian Christopher J, Deng Hong-Wen, Zhang Shujun, Zhao Ming

Abstract excerpt

Cytoskeleton microtubules regulate various cell signaling pathways that are involved in bone cell function. We recently reported that inhibition of microtubule assembly by microtubule-targeting drugs stimulates osteoblast differentiation and bone formation. To further elucidate the role of microtubules in bone homeostasis, we characterized the skeletal phenotype of mice null for stathmin, an endogenous protein...

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PMID: 21557310
DOI: 10.1002/jbmr.419

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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