Article
Tristetraprolin regulates the skeletal phenotype and osteoclastogenic potential through monocytic myeloid-derived suppressor cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jan 2024
Zhang Lixia, Kwack Kyu Hwan, Thiyagarajan Ramkumar, Mullaney Kylie K, Lamb Natalie A, Bard Jonathan E, Sohn Jiho, Seldeen Kenneth L, Arao Yukitomo, Blackshear Perry J, Abrams Scott I, Troen Bruce R, Kirkwood Keith L
Abstract excerpt
Tristetraprolin (TTP; also known as NUP475, GOS24, or TIS11), encoded by Zfp36, is an RNA-binding protein that regulates target gene expression by promoting mRNA decay and preventing translation. Although previous studies have indicated that TTP deficiency is associated with systemic inflammation and a catabolic-like skeletal phenotype, the mechanistic underpinnings remain unclear. Here, using both TTP-deficient...
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