Mesoderm-specific Stat3 deletion affects expression of Sox9 yielding Sox9-dependent phenotypes.

Abstract excerpt

To date, mutations within the coding region and translocations around the SOX9 gene both constitute the majority of genetic lesions underpinning human campomelic dysplasia (CD). While pathological coding-region mutations typically result in a non-functional SOX9 protein, little is known about what mechanism(s) controls normal SOX9 expression, and subsequently, which signaling pathways may be interrupted by...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Chondrocytes
• Share to Chondrogenesis
• Share to Gene Expression Regulation, Developmental