Article
Skeletal dysplasia and male infertility locus on mouse chromosome 9.
Genomics - 1 Jun 2004
Cha K B, Karolyi I J, Hunt A, Wenglikowski A M, Wilkinson J E, Dolan D F, Dootz G, Finnegan A A, Seasholtz A F, Hankenson K D, Siracusa L D, Camper S A
Abstract excerpt
In mice and humans, growth insufficiency and male infertility are common disorders that are genetically and phenotypically complex. We describe a spontaneously arising mouse mutant, chagun, that is affected by both dwarfism and male infertility. Dwarfism disproportionately affects long bones and is characterized by a defect in the proliferative zone of chondrocytes in the growth plate. Gonads of mutant males are...
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