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Glial Sphingosine-Mediated Epigenetic Regulation Stabilizes Synaptic Function inDrosophilaModels of Alzheimer's Disease

5 Sept 2023

Abstract excerpt

Destabilization of neural activity caused by failures of homeostatic regulation has been hypothesized to drive the progression of Alzheimer's Disease (AD). However, the underpinning mechanisms that connect synaptic homeostasis and the disease etiology are yet to be fully understood. Here, we demonstrated that neuronal overexpression of amyloid β (Aβ) causes abnormal histone acetylation in peripheral glia and...

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PMID: 37669862
DOI: 10.1523/jneurosci.0515-23.2023

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