Article

Only Zn <sup>2+</sup> and Fe <sup>2+</sup> out of 12 cations can fold ALS-linked nascent hSOD1

2023-04-29

Abstract excerpt

153-residue copper-zinc superoxide dismutase 1 (hSOD1) is the first gene whose mutation was linked to FALS, while wild-type hSOD1 aggregation is associated with SALS. So far >180 ALS-causing mutations have been identified within hSOD1, but the underlying mechanism still remains enigmatic. Mature hSOD1 is extremely stable constrained by a disulfide bridge to adopt a Greek-key β-barrel fold that houses copper and zi...

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Literature Corpus work: 0c607e58-ce6f-5a72-8109-8b8440ccce0e
DOI: 10.1101/2023.04.29.538825

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