Article
A distal ligand mutes the interaction of hydrogen sulfide with human neuroglobin.
The Journal of biological chemistry - 21 Apr 2017
Ruetz Markus, Kumutima Jacques, Lewis Brianne E, Filipovic Milos R, Lehnert Nicolai, Stemmler Timothy L, Banerjee Ruma
Abstract excerpt
Hydrogen sulfide is a critical signaling molecule, but high concentrations cause cellular toxicity. A four-enzyme pathway in the mitochondrion detoxifies H2S by converting it to thiosulfate and sulfate. Recent studies have shown that globins like hemoglobin and myoglobin can also oxidize H2S to thiosulfate and hydropolysulfides. Neuroglobin, a globin enriched in the brain, was reported to bind H2S tightly and was...
Topics
- Catalysis
- Crystallography, X-Ray
- Cysteine
- Electron Spin Resonance Spectroscopy
- Globins
- Heme
- Hemoglobins
- Histidine
- Humans
- Hydrogen Sulfide
- Hydrogen-Ion Concentration
- Kinetics
- Ligands
- Mass Spectrometry