Article

Zinc(II) binding on human wild-type ISCU and Met140 variants modulates Fe-S complex activity

2018-02-10

Abstract excerpt

<h4>ABSTRACT</h4> The human de novo iron-sulfur (Fe-S) assembly complex consists of the cysteine desulfurase NFS1, accessory protein ISD11, scaffold protein ISCU, and allosteric activator frataxin (FXN). FXN has been shown to bind the NFS1-ISD11-ISCU complex (SDU), to activate the desulfurase activity and thus Fe-S cluster biosynthesis. Conversely, in the absence of FXN, the NFS1-ISD11 (SD) complex was reported...

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Literature Corpus work: 62190326-15a7-53a9-b787-7352ca81eda9
DOI: 10.1101/262477

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