Article

Cobalt-sulfur coordination chemistry drives B <sub>12</sub> loading onto methionine synthase

2023-07-26

Abstract excerpt

Cobalt-sulfur (Co-S) coordination is labile to both oxidation and reduction chemistry and is rarely seen in Nature. Cobalamin (or vitamin B 12 ) is an essential cobalt-containing organometallic cofactor in mammals, and is escorted via an intricate network of chaperones to a single cytoplasmic target, methionine synthase. In this study, we report that the human cobalamin trafficking protein, MMADHC, exploits the c...

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Literature Corpus work: 096c1cbd-b90a-5354-9d73-83f10a78252c
DOI: 10.1101/2023.07.25.550549

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