Article

Investigation of the Activity of LNA-Modified Phosphorothioate Oligonucleotides Against HIV-1

2025-06-18

Abstract excerpt

This study investigated the antiretroviral efficacy, toxicity profile, and cellular uptake of LNA-modified oligonucleotides within an in vitro HIV infection model. Phosphorothioate (PS) oligonucleotides, designed to bind conserved regions of the HIV-1 genome, were modified at the 3′ and/or 5′ ends with LNA nucleotides. The antiviral properties of oligonucleotides against HIV-1 subtype A6 were evaluated...

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Literature Corpus work: 7f72b9f2-456a-5349-b0c8-9313309c5f12
DOI: 10.20944/preprints202506.1545.v1

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