Article
Identification of a methylated oligoribonucleotide as a potent inhibitor of HIV-1 reverse transcription complex.
Nucleic acids research - 1 Jul 2011
Grigorov Boyan, Bocquin Anne, Gabus Caroline, Avilov Sergey, Mély Yves, Agopian Audrey, Divita Gilles, Gottikh Marina, Witvrouw Myriam, Darlix Jean-Luc
Abstract excerpt
Upon HIV-1 infection of a target cell, the viral reverse transcriptase (RT) copies the genomic RNA to synthesize the viral DNA. The genomic RNA is within the incoming HIV-1 core where it is coated by molecules of nucleocapsid (NC) protein that chaperones the reverse transcription process. Indeed, the RT chaperoning properties of NC extend from the initiation of cDNA synthesis to completion of the viral DNA. New...
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