Article
DNA encapsidation as a target for anti-herpesvirus drug therapy.
Antiviral research - 1 Jul 2003
Visalli Robert J, van Zeijl Marja
Abstract excerpt
The current repertoire of approved anti-herpesviral drugs consists primarily of nucleoside analogues that inhibit viral replication by targeting the virus-encoded DNA polymerase. This class of agents has been critical in controlling infections by herpes simplex, varicella zoster, and cytomegalovirus. However, because nucleoside analogues share a similar mechanism of action, treatment options are limited once...
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