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Article

Newly designed six-membered azasugar nucleotide-containing phosphorothioate oligonucleotides as potent human immunodeficiency virus type 1 inhibitors.

Antimicrobial agents and chemotherapy - 1 Oct 2005

Lee Dong-Seong, Jung Kyeong-Eun, Yoon Cheol-Hee, Lim Hong, Bae Yong-Soo

Abstract excerpt

A series of modified oligonucleotides (ONs), characterized by a phosphorothioate (P S) backbone and a six-membered azasugar (6-AZS) as a sugar substitute in a nucleotide, were newly synthesized and assessed for their ability to inhibit human immunodeficiency virus type 1 (HIV-1) via simple treatment of HIV-1-infected cultures, without any transfection process. While unmodified P S ONs exhibited only minor...

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Identifiers

PMID: 16189087
DOI: 10.1128/AAC.49.10.4110-4120.2005
PMCID: PMC1251495

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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