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Article

Methylene bisphosphonates as the inhibitors of HIV RT phosphorolytic activity.

Biochimie - 1 Aug 2016

Yanvarev D V, Korovina A N, Usanov N N, Khomich O A, Vepsäläinen J, Puljula E, Kukhanova M K, Kochetkov S N

Abstract excerpt

The structure-function analysis of 36 methylenebisphosphonates (BPs) as inhibitors of the phosphorolytic activity of native and drug-resistant forms of HIV-1 reverse transcriptase (RT) was performed. It was shown that with the increase of the inhibitory potential of BPs towards the phosphorolytic activity raises their ability to inhibit the RT-catalyzed DNA elongation. Herein, we report the impact of the...

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Identifiers

PMID: 27230835
DOI: 10.1016/j.biochi.2016.05.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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