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Article

Modular assembly of purine-like bisphosphonates as inhibitors of HIV-1 reverse transcriptase.

Journal of medicinal chemistry - 11 Sept 2014

Lacbay Cyrus M, Mancuso John, Lin Yih-Shyan, Bennett Nicholas, Götte Matthias, Tsantrizos Youla S

Abstract excerpt

Bisphosphonates can mimic the pyrophosphate leaving group of the nucleotidyl transfer reaction and effectively inhibit RNA/DNA polymerases. In a search of HIV-1 reverse transcriptase (RT) inhibitors, a new chemotype of nonhydrolyzable purine diphosphate mimic was synthesized. A modular synthetic protocol was developed, utilizing 2-amino-6-(methylthio)-4-(trimethylsilyl)nicotinonitrile as the key synthon in the...

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Identifiers

PMID: 25144111
DOI: 10.1021/jm501010f

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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